An intelligent microfluidic synthesis platform designed for the laboratory: TFR, FRR, preparation volume and every parameter fully digitized — one-step formation, controlled particle size, high batch-to-batch reproducibility. The ideal tool for LNP, liposome and polymeric nanoparticle formulation screening.
NP-S2 is based on microfluidic precision mixing: lipid and aqueous phases mix instantaneously inside the chip at the set high flow-rate ratio, and supersaturation-driven self-assembly completes within milliseconds — yielding uniform nanoparticles with high encapsulation efficiency and minimal batch-to-batch variation.
Continuously tune particle size and distribution across 30–200 nm via TFR and FRR.
Digitized parameters eliminate operator variability — extremely low batch CV, data directly comparable across runs.
LNPs, liposomes, PLGA polymeric nanoparticles, exosome loading and more — one instrument covers them all.
Guided touch operation — newcomers are productive within 10 minutes; accepts standard 1–20 mL Luer syringes.
Real-time pressure and flow display with automatic fault stop protection — the entire run is traceable.
Minutes per preparation with samples from 0.4 mL — significant savings in precious sample and development time.
| NP size range | 30 – 200 nm |
|---|---|
| Flow rate ratio (FRR) | 10:1 – 1:30 |
| Total flow rate (TFR) | 0 – 200 mL/min |
| Flow rate accuracy | Error ≤ 2% |
| Sample preparation volume | 0.4 – 40 mL |
| Syringe types | Most commercial Luer-syringes (1 – 20 mL) |
| Chip material | Standard COC micromixer chip; optional 316L stainless / glass |
| Break pressure | 5 MPa |
| Compatible reagents | COC chip: methanol, ethanol, isopropanol, acetonitrile, DMF, etc. Metal-glass chip: compatible with most aggressive organic solvents |
| Nanoparticle types | LNP, liposome, polymeric NP, etc. |
| Loadable payloads | DNA, RNA, RNP, small molecules, peptides, etc. |
| Channels | 2 channels |
|---|---|
| Adjustable parameters | TFR, FRR, preparation volume, syringe specification |
| Control | Touch screen; optional PC control + audit trail |
| Environment | 5 – 40 °C, relative humidity < 70% |
| Power | 220 V ± 5 V, 50 Hz, 10 A |
| Dimensions (L×W×H) | 39 × 28.5 × 36 cm |
NP-S2 comes standard with a high-performance COC polymer micromixer chip that covers daily preparation of most LNP / liposome formulations; for aggressive organic solvents or high-pressure scenarios, 316L stainless steel and glass chips are available to cover the development needs of polymeric nanoparticles and beyond.
Microvolume screening from 0.4 mL to rapidly explore lipid composition and process parameter space.
Stable, controllable particle size and encapsulation efficiency for preformulation of loaded liposomes.
Nanoprecipitation of PLGA and similar systems for sustained-release formulation development.
Engineered loading of exosomes to rapidly explore novel delivery carriers.
One-stop preparation and optimization of DNA / RNA / RNP delivery systems.
Visualized parameter demonstration — an ideal platform for nano-formulation training.
8-channel parallel synthesis, as little as 60 μL per channel, 20–30 s per run, ~95% reagent savings.
NP-HT.S details
A 0–500 mL/min three-channel pilot platform with optional heating and in-line dilution, 21 CFR Part 11 compliant — scale NP-S2 formulations seamlessly.
NP-M1 detailsCall +86 21 5086 1716, or leave a message about your application.
