A modular pilot-scale platform for LNPs, polymeric nanoparticles and emulsions: three-channel liquid path, non-contact flow feedback, optional liquid heating and in-line dilution, software compliant with 21 CFR Part 11 — carrying laboratory formulations smoothly toward volume production.
NP-M1 is a pilot-scale nano-formulation preparation platform supporting continuous production of LNPs, polymeric nanoparticles, emulsions and more. Its modular design allows flexible configuration of liquid heating, flow feedback, in-line dilution and automatic pre/post waste switching; the software has a built-in audit trail that meets 21 CFR Part 11, with non-standard customization available.
Houses two chips with multi-stage serial mixing; supports LNPs, PLGA nanoparticles, liposomes and exosome loading. Chips are quick to swap and clean for an efficient, clean workflow.
Modules can run independently or as a coordinated line with live visualization of synthesis progress and instrument status. Three-tier permissions, password protection, e-signatures and audit trail ensure compliance and data integrity.
Ruby-valve high-pressure plunger pumps perform stably under load; the 316L stainless liquid path can be replaced, disassembled and cleaned as a whole — meeting cGMP cleaning-validation requirements.
Three independent delivery channels support continuous feeding with ±1% flow accuracy:
Dual non-contact mass flow meters (0–20 kg/h and 0–30 kg/h) monitor in real time, with ample range margin for high-density liquids to keep measurement accuracy consistent.
Sample inlets, tubing and chip heated together from ambient to 80 °C with ±2 °C accuracy, meeting the temperature requirements of various nanoparticle syntheses.
Real-time response and fast switching; a carefully designed flow path eliminates any risk of waste backflow, ensuring product purity and stability.
Three standardized chip designs — Vortex, impinging jet (T-mix) and split-and-recombine (SAR) — in 316L stainless steel or Hastelloy, with custom metal chips available on request.
Non-standard customization supported: channel configuration, heating modules, in-line dilution units and more can be combined to your process. An advanced chip design and manufacturing team provides end-to-end support for special flow structures.
Three standardized mixing architectures plus fully custom flow paths, covering every mixing need from process development to pilot production.
Outstanding at production scale: simple structure, low flow resistance and high flow capacity — the preferred design of leading vaccine companies and nanoparticle plants. Multiple channel widths tailor to different flow requirements.
A newer architecture with 2–4 liquid inlets. Matches T-mix at low flows; at higher flows it delivers smaller particle size and lower PDI. Also widely used for PLGA nanoparticles and liposomes.
The standardized SAR chip suits gentle stepwise mixing; for special designs and processes, our chip team provides full-custom flow path services.
| Chip type | Material | Max. flow rate | Max. pressure |
|---|---|---|---|
| Impinging jet (T-mix) | 316L stainless steel (or Hastelloy) | 200 / 300 / 400 mL/min | 10 MPa |
| Vortex | 316L stainless steel (or Hastelloy) | 500 mL/min | 10 MPa |
| Custom | 316L stainless steel (or Hastelloy) | On request | 10 MPa |
| Flow rate range | 0 – 500 mL/min |
|---|---|
| Tubing hold-up volume | < 15 mL (dual high-pressure plunger pumps + vortex chip, typical configuration, excluding external tubing) |
| Sample temperature control | Ambient – 80 °C (optional heating module, ±2 °C accuracy) |
| Chip architectures | Impinging jet (T-mix), vortex, split-and-recombine (SAR) |
| Chip material | 316L stainless steel or Hastelloy |
| Tubing material | 316L stainless steel |
| Channel configuration | 2 high-pressure lines + 1 ambient-pressure line |
|---|---|
| High-pressure channel flow | Channel 1: 0–200 mL/min; Channel 2: 0–300 mL/min (±1% accuracy, max. working pressure 10 MPa) |
| Ambient channel flow | 0 – 2000 mL/min |
| Flow meters | 2 non-contact mass flow meters (0–20 kg/h; 0–30 kg/h) |
| Control | External PC control (with audit trail, 21 CFR Part 11 compliant) |
| Environment | 4 – 40 °C; humidity < 90% |
| Power | 220 V ± 5%, 50 Hz, 10 A (transformer on request) |
| Dimensions (L×W×H) | 62 × 75 × 107 cm |
Process scale-up and pilot batches of mRNA vaccine and nucleic acid drug LNPs, with parameters consistent with the benchtop platforms.
Pilot preparation of biodegradable polymer nanoparticles such as PLGA, generating process data for clinical translation.
Continuous pilot production of active-ingredient nanocarriers and emulsion systems, improving uniformity and efficiency.
From continuous feeding and real-time flow feedback through multi-stage mixing, in-line dilution and automatic waste switching, NP-M1 organizes pilot production into one stable line — every step recorded by software to satisfy audit and traceability requirements.
8-channel parallel synthesis, as little as 60 μL per channel, 20–30 s per run, ~95% reagent savings.
NP-HT.S details
0.4–40 mL microvolume preparation, touch control, 30–200 nm — built for formulation screening, with parameters consistent with NP-M1.
NP-S2 detailsCall +86 21 5086 1716, or tell us your process requirements.
